Inhibitors of HIV-1 integrase from Dioscorea bulbifera
نویسندگان
چکیده
Journal: Songklanakarin Journal of Science and Technology Manuscript ID SJST-2015-0185.R2 Manuscript Type: Original Article Date Submitted by the Author: 24-Oct-2015 Complete List of Authors: Tewtrakul, Supinya; Fac. of Pharmaceutical Sciences, Prince of Songkla University, Pharmacognosy and Pharmaceutical Botany Chaniad, Prapaporn; Fac. of Pharm. Sci., Prince of Songkla University, Wattanapiromsakul, Chatchai; Fac. of Pharm. Sci., Prince of Songkla University, Painwanit, Somsak; Fac. of Sci., Chulalongkorn University, Keyword: Chemistry and Pharmaceutical Sciences
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Progress in HIV-1 integrase inhibitors: A review of their chemical structure diversity
HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue in human cells and its essential role in HIV-1 replication, IN inhibition represents an attractive therapeutic target for HIV-1 treatment. Since identification of IN as a promising therapeutic target, a major progress h...
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